Heterologe Expression der
Natriumpumpe in Hefen
und
Untersuchung
der Struktur/Funktions-Beziehung des Enzyms mit Hilfe von Mutanten und
Hybridkonstrukten und unter Einsatz von Palytoxin.
Expression und Analyse der
Eigenschaften des
renalen Na+/PO4-Cotransporters
in Hefen.
Untersuchungen über
die kausalen
Zusammenhänge
zwischen Ionentransport und Bluthochdruck.
W. Schoner, G. Scheiner-Bobis: Endogene herzaktive Steroide -
eine neue Klasse von Steroidhormonen. [Endogenous cardioactive steroids
- a new class of steroid hormones.] Dtsch. Med. Wochenschr. 134 (2009)
632-636.
G. Scheiner-Bobis (March 2009) Gene Expression in Yeast. In:
Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd:
Chichester. DOI: 10.1002/9780470015902.a0002666.pub2.
C. Hauck, T. Potter,
M. Bartz, T. Wittwer, T. Wahlers, U. Mehlhorn, G. Scheiner-Bobis, A.A.
McDonough, W. Bloch, R.H.G. Schwinger, J. Müller-Ehmsen: Isoform
specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1. Eur. J. Pharmacol. 622 (2009) 7-14.
2008
W.
Schoner, G. Scheiner-Bobis: Role of endogenous cardiotonic steroids in
sodium homeostasis. Nephrol. Dial. Transplant. 23 (2008) 2723-2729.
G. Scheiner-Bobis, W. Schoner: Na+/K+-ATPase.
Encyclopedia
of Molecular Pharmacology (Offermanns, Stefan; Rosenthal, Walter, Eds)
2nd Edition (2008) Springer-Verlag, Heidelberg, Berlin, New York, pp.
812-819.
2007
W.
Schoner, G. Scheiner-Bobis: Endogenous and exogenous cardiac
glycosides: Their roles in hypertension, salt metabolism, and cell
growth (invited review). Am. J. Phyiol. Cell Physiol. 293 (2007)
509-536.
A. Kulikov, A. Eva, U. Kirch, A. Boldyrev. G.
Scheiner-Bobis:
Ouabain activates signaling pathways associated with cell death in
human neuroblastoma. Biochim. Biophys. Acta 1768 (2007) 1691-1702.
W. Schoner and G. Scheiner-Bobis: Endogenous and Exogenous
Cardiac Glycosides and their Mechanisms of Action. Am. J. Cardiovasc.
Drugs 7 (3) (2007) 173-189.
2006
Schoner, W., Bauer, N., Scheiner-Bobis, G.: "Endogenes
Digitalis" - der lange Weg vom herzwirksamen pflanzlichen Toxin zum
Hormon der Säuger. Tierärztl Prax 34(K) (2006)
389-397.
Eva, A., Kirch, U., Scheiner-Bobis, G.: Signaling pathways
involving the sodium pump stimulate NO production in endothelial cells.
Biochim. Biophys. Acta 1758 (2006) 1809-1814.
G. Scheiner-Bobis, A. Eva, U. Kirch: Signalling pathways
involving sodium pump stimulate endothelin-1 secretion and nitric oxide
production in endothelial cells. Cell. Mol. Biol. 52 (2006) 58-63.
2005
Schoner, W., Scheiner-Bobis, G.: Endogenous cardiac
glycosides:
hormones using the sodium pump as signal transducer. Semin. Nephrol. 25
(2005) 343-351.
2004
Su, P., Scheiner-Bobis, G.: Lys691
and Asp714
of
the Na+/K+-ATPase a
subunit
are essential for phosphorylation, dephosphorylation, and enzyme
turnover.
Biochemistry 43 (2004) 4731-4740.
Saunders, R., Scheiner-Bobis, G.: Ouabain stimulates
endothelin
release
and expression in human endothelial cells without inhibiting the sodium
pump. Eur. J. Biochem. 271 (2004) 1054-1062.
Susanne Becker, Heike Schneider and Georgios
Scheiner-Bobis: The
highly conserved extracellular peptide, DSYG(893-896), is a critical
structure for sodium pump function. Eur. J. Biochem. 271 (2004)
3821-3831.
2002
Scheiner-Bobis, G., Hübschle, T. and Diener, M.:
Action of
palytoxin
on apical H+/K+-ATPase in
rat colon. Eur. J.
Biochem.
269 (2002) 3905-3911.
Scheiner-Bobis, G.: The sodium pump. Eur. J. Biochem. 269
(2002)
2424-2433.
2001
Farley, R.A., Schreiber, S., Wang, S.G., Scheiner-Bobis,
G.: A
hybrid
between
Na+,K+-ATPase and H+,K+-ATPase
is sensitive to palytoxin, ouabain, and SCH 28080. J. Biol. Chem. 276
(2001)
2608-2615.
Jäger, H., Wozniak, G., Akinturk, I.H., Hehrlein,
F.W.,
Scheiner-Bobis,
G.: Expression of sodium pump isoforms and other sodium or calcium ion
transporters in the heart of hypertensive patient. Biochim. Biophys.
Acta
1513 (2001) 149-159.
G. Scheiner-Bobis, W. Schoner: A fresh facet for ouabain
action.
Nature
Medicine 7 (2001) 1288-1289.
2000
G. Scheiner-Bobis: Ion-transporting ATPases and ion
channels:
fundamentally
similar mechanisms of ion transport? In: Na/K-ATPase and
Related
ATPases (K. Taniguchi and S. Kaya, eds.) Elsevier Science B.V.,
Amsterdam,
2000, pp. 177-185.
1999
G. Scheiner-Bobis and S. Schreiber: Glutamic acid 472 and
lysine
480 of
the sodium pump a1
subunit are essential
for
activity. Their conservation in pyrophosphatases suggests their
involvement
in recognition of ATP phosphates. Biochemistry 38 (1999) 9198-9208.
F. Bernhardt, W. Schoner, B. Schroeder, G. Breves and G.
Scheiner-Bobis:
Functional expression and characterization of the wild-type mammalian
renal
cortex sodium/phosphate cotransporter and an 215R
mutant
in Saccharomyces cerevisiae. Biochemistry 38 (1999)
13551-13559.
1998
G. Scheiner-Bobis: Ion-transporting ATPases as ion
channels.
Naunyn-Schmiedeberg’s
Arch. Pharmacol. 357 (1998) 477-481.
G. Scheiner-Bobis: Ion pumps and ion channels:
Fundamentally
similar
mechanisms
of ion transport? B.I.F. Futura 13 (1998) 241-247.
1997
H. Schneider and G. Scheiner-Bobis. Involvement of the
M7/M8
extracellular
loop of the sodium pump a subunit in ion transport. Structural and
functional
homology to P-loops of ion channels. J. Biol. Chem. 272:16158-16165
(1997).
G. Scheiner-Bobis and H. Schneider. Palytoxin-induced
channel
formation
within the Na+,K+-ATPase
does not require a
catalytically
active enzyme. Eur. J. Biochem. 248:717-723 (1997).
1996
J. Redondo, B. Fiedler and G. Scheiner-Bobis.: Palytoxin
induced
Na+-influx
into yeast cells expressing the mammalian sodium pump is due to the
formation
of a channel within the enzyme. Mol. Pharmacol. 49 (1996) 49-57.
B. Fiedler and G. Scheiner-Bobis: Transmembrane Topology of
a-
and b-Subunits of Na+,K+-ATPase
Derived from b-Galactosidase
fusion
proteins
expressed in yeast. J. Biol. Chem. 271 (1996) 29312-29320.
1994
C.M. Tran, G. Scheiner-Bobis, W.Schoner and R.A. Farley.:
Identification
of an amino acid in the ATP-binding site of Na+,K+-ATPase
after photochemical labelling with 8-azido-ATP. Biochemistry 33 (1994)
4140-4147.
R. A. Farley, K. A. Eakle, G. Scheiner-Bobis and K. Wang.:
Expression
of
functional Na+/K+-ATPase
in Yeast. Proc. VIIth
International
Conference on the Sodium Pump (E. Bamberg and W. Schoner, eds.,
Steinkopf
Verlag, Darmstadt, FRG) (1994) 11-20.
D. Meyer zu Herringdorf, E. Habermann and G.
Scheiner-Bobis.:
Palytoxin
induces K+ release from yeast cells expressing Na+,K+-ATPase.
Proc. VIIth International Conference on the Sodium Pump (E. Bamberg and
W. Schoner, eds., Steinkopf Verlag, Darmstadt, FRG) (1994) 385-388.
W. Schoner, D. Thönges, E. Hamer, R. Antolovic, E.
Buxbaum,
M.
Willeke,
E. H. Serpersu and G. Scheiner-Bobis.: Is the sodium pump a functional
dimer? Proc. VIIth International Conference on the Sodium Pump (E.
Bamberg
and W. Schoner, eds., Steinkopf Verlag, Darmstadt, FRG) (1994) 332-341.
G. Scheiner-Bobis, D. Meyer zu Heringdorf, M. Christ and E.
Habermann.:
Palytoxin induces K+ efflux from yeast cells
expressing the
mammalian sodium pump. Mol. Pharmacol. 45 (1994) 1132-1136.
G. Scheiner-Bobis and R. A. Farley.: Subunit requirements
for
expression
of functional sodium pumps in yeast cells. Biochim. Biophys. Acta 1193
(1994) 226-234.
1993
G. Scheiner-Bobis, J. Antonipillai, and R. A. Farley.:
Simultaneous
binding
of phosphate and TNP-ADP to the FITC-modified Na+,K+-ATPase.
Biochemistry 32 (1993) 9592-9599.
J. Gäbler, I. Nolte, G. Scheiner-Bobis and E.
Eigenbrodt.:
The
influence
of storage time on the nucleotide concentration of canine platelets. J.
Vet. Med. A 40 (1993) 546-554.
1992
G. Scheiner-Bobis, W. Mertens, M. Willecke and W. Schoner.:
Synthesis
and
biochemical characterization of the new sulfhydryl-reactive ATP
analogue
8-thiocyano-ATP. Its interaction with Na,K-ATPase and kinases.
Biochemistry
31 (1992) 2107-2113.
1991
L. D. Faller, R. A. Diaz, G. Scheiner-Bobis and R. A.
Farley.:
Temperature
dependence of the rates of the conformational changes reported by
fluorescein
5'-isothiocyanate modification of the H+,K+
and
the
Na+,K+-ATPases.
Biochemistry 30 (1991) 3503-3510.
