Institut für Virologie, Justus-Liebig-Universität Gießen

Publikationen der Arbeitsgruppe Wengler

Koschinski A, Wengler G, Wengler G, Repp H.
The membrane proteins of flaviviruses form ion-permeable pores in the target membrane after fusion: identification of the pores and analysis of their possible role in virus infection.
J Gen Virol. 2003 Jul;84(Pt 7):1711-21.
PMID: 12810864

Wengler G, Koschinski A, Wengler G, Dreyer F.
Entry of alphaviruses at the plasma membrane converts the viral surface proteins into an ion-permeable pore that can be detected by electrophysiological analyses of whole-cell membrane currents.
J Gen Virol. 2003 Jan;84(Pt 1):173-81.
PMID: 12533714

Wengler G, Wengler G.
In vitro analysis of factors involved in the disassembly of Sindbis virus cores by 60S ribosomal subunits identifies a possible role of low pH.
J Gen Virol. 2002 Oct;83(Pt 10):2417-26.
PMID: 12237423

Lescar J, Roussel A, Wien MW, Navaza J, Fuller SD, Wengler G, Wengler G, Rey FA.
The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH.
Cell. 2001 Apr 6;105(1):137-48.
PMID: 11301009

Yamshchikov VF, Wengler G, Perelygin AA, Brinton MA, Compans RW.
An infectious clone of the West Nile flavivirus.
Virology. 2001 Mar 15;281(2):294-304.
PMID: 11277701

Wengler G, Wengler G, Rey FA.
The isolation of the ectodomain of the alphavirus E1 protein as a soluble hemagglutinin and its crystallization.
Virology. 1999 May 10;257(2):472-82.
PMID: 10329557

Gros C, Linder M, Wengler G, Wengler G.
Analyses of disulfides present in the rubella virus E1 glycoprotein.
Virology. 1997 Apr 14;230(2):179-86.
PMID: 9143273

Choi HK, Lu G, Lee S, Wengler G, Rossmann MG.
Structure of Semliki Forest virus core protein.
Proteins. 1997 Mar;27(3):345-59.
PMID: 9094737

Choi HK, Lee S, Zhang YP, McKinney BR, Wengler G, Rossmann MG, Kuhn RJ.
Structural analysis of Sindbis virus capsid mutants involving assembly and catalysis.
J Mol Biol. 1996 Sep 20;262(2):151-67. Erratum in: J Mol Biol 1997 Feb 28;266(3):633-4.
PMID: 8831786

Wengler G, Gros C, Wengler G.
Analyses of the role of structural changes in the regulation of uncoating and assembly of alphavirus cores.
Virology. 1996 Aug 1;222(1):123-32.
PMID: 8806493

Lee S, Owen KE, Choi HK, Lee H, Lu G, Wengler G, Brown DT, Rossmann MG, Kuhn RJ.
Identification of a protein binding site on the surface of the alphavirus nucleocapsid and its implication in virus assembly.
Structure. 1996 May 15;4(5):531-41.
PMID: 8736552

Gros C, Wengler G.
Identification of an RNA-stimulated NTPase in the predicted helicase sequence of the Rubella virus nonstructural polyprotein.
Virology. 1996 Mar 1;217(1):367-72.
PMID: 8599224

Gros C, Wengler G.
Large scale purification of rubella virus and the isolation of native viral core protein.
Arch Virol. 1995;140(4):757-64.
PMID: 7794116

Wengler G, Wengler G.
The NS 3 nonstructural protein of flaviviruses contains an RNA triphosphatase activity.
Virology. 1993 Nov;197(1):265-73.
PMID: 8212562

Tong L, Wengler G, Rossmann MG.
Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures.
J Mol Biol. 1993 Mar 5;230(1):228-47.
PMID: 8450538

Wengler G, Wurkner D, Wengler G.
Identification of a sequence element in the alphavirus core protein which mediates interaction of cores with ribosomes and the disassembly of cores.
Virology. 1992 Dec;191(2):880-8.
PMID: 1333127

Choi HK, Tong L, Minor W, Dumas P, Boege U, Rossmann MG, Wengler G.
Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion.
Nature. 1991 Nov 7;354(6348):37-43.
PMID: 1944569

Wengler G, Wengler G.
The carboxy-terminal part of the NS 3 protein of the West Nile flavivirus can be isolated as a soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPase.
Virology. 1991 Oct;184(2):707-15.
PMID: 1716026

Wengler G.
A possible role of the viral core protein in the regulation of assembly and disassembly of alphavirus cores.
Behring Inst Mitt. 1991 Jul;(89):209-16. Review.
PMID: 1656932

Wengler G, Czaya G, Farber PM, Hegemann JH.
In vitro synthesis of West Nile virus proteins indicates that the amino-terminal segment of the NS3 protein contains the active centre of the protease which cleaves the viral polyprotein after multiple basic amino acids.
J Gen Virol. 1991 Apr;72 ( Pt 4):851-8.
PMID: 1826736

Wengler G, Wengler G, Nowak T, Castle E.
Description of a procedure which allows isolation of viral nonstructural proteins from BHK vertebrate cells infected with the West Nile flavivirus in a state which allows their direct chemical characterization.
Virology. 1990 Aug;177(2):795-801.
PMID: 2142559

Boege U, Cygler M, Wengler G, Dumas P, Tsao J, Luo M, Smith TJ, Rossmann MG.
Sindbis virus core protein crystals.
J Mol Biol. 1989 Jul 5;208(1):79-82.
PMID: 2769756

Wengler G, Wengler G.
Cell-associated West Nile flavivirus is covered with E?M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release.
J Virol. 1989 Jun;63(6):2521-6.
PMID: 2724410

Nowak T, Farber PM, Wengler G, Wengler G.
Analyses of the terminal sequences of West Nile virus structural proteins and of the in vitro translation of these proteins allow the proposal of a complete scheme of the proteolytic cleavages involved in their synthesis.
Virology. 1989 Apr;169(2):365-76.
PMID: 2705302

Wengler G, Wengler G.
An analysis of the antibody response against West Nile virus E protein purified by SDS-PAGE indicates that this protein does not contain sequential epitopes for efficient induction of neutralizing antibodies.
J Gen Virol. 1989 Apr;70 ( Pt 4):987-92.
PMID: 2471801

Wengler G, Wengler G, Nowak T, Wahn K.
Analysis of the influence of proteolytic cleavage on the structural organization of the surface of the West Nile flavivirus leads to the isolation of a protease-resistant E protein oligomer from the viral surface.
Virology. 1987 Sep;160(1):210-9.
PMID: 3629975

Castle E, Wengler G.
Nucleotide sequence of the 5'-terminal untranslated part of the genome of the flavivirus West Nile virus.
Arch Virol. 1987;92(3-4):309-13.
PMID: 3813889

Nowak T, Wengler G.
Analysis of disulfides present in the membrane proteins of the West Nile flavivirus.
Virology. 1987 Jan;156(1):127-37.
PMID: 3811228

Wengler G.
The mode of assembly of alphavirus cores implies a mechanism for the disassembly of the cores in the early stages of infection. Brief review.
Arch Virol. 1987;94(1-2):1-14. Review. No abstract available.
PMID: 3034197

Wengler G, Castle E.
Analysis of structural properties which possibly are characteristic for the 3'-terminal sequence of the genome RNA of flaviviruses.
J Gen Virol. 1986 Jun;67 ( Pt 6):1183-8.
PMID: 3011975

Castle E, Leidner U, Nowak T, Wengler G, Wengler G.
Primary structure of the West Nile flavivirus genome region coding for all nonstructural proteins.
Virology. 1986 Feb;149(1):10-26.
PMID: 3753811

Wengler G, Castle E, Leidner U, Nowak T, Wengler G.
Sequence analysis of the membrane protein V3 of the flavivirus West Nile virus and of its gene.
Virology. 1985 Dec;147(2):264-74.
PMID: 3855247

Castle E, Nowak T, Leidner U, Wengler G, Wengler G.
Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins.
Virology. 1985 Sep;145(2):227-36.
PMID: 2992152

Wengler G, Wengler G.
Identification of a transfer of viral core protein to cellular ribosomes during the early stages of alphavirus infection.
Virology. 1984 Apr 30;134(2):435-42.
PMID: 6545074

Wengler G, Wengler G, Boege U, Wahn K.
Establishment and analysis of a system which allows assembly and disassembly of alphavirus core-like particles under physiological conditions in vitro.
Virology. 1984 Jan 30;132(2):401-12.
PMID: 6702103

Boege U, Wengler G, Wittmann-Liebold B.
The core protein of alphaviruses. 2. Purification of peptides and complete amino-acid sequence of Sindbis virus core protein.
Eur J Biochem. 1983 Jun 15;133(2):415-26.
PMID: 6852051

Boege U, Wengler G, Wittmann-Liebold B.
The core protein of alphaviruses. 1. Purification of peptides and complete amino-acid sequence of Semliki Forest virus core protein.
Eur J Biochem. 1983 Jun 15;133(2):405-14.
PMID: 6852050

Boege U, Heinz FX, Wengler G, Kunz C.
Amino acid compositions and amino-terminal sequences of the structural proteins of a flavivirus, European Tick-Borne Encephalitis virus.
Virology. 1983 Apr 30;126(2):651-7.
PMID: 6305006

Wengler G, Wengler G, Gross HJ.
Terminal sequences of Sindbis virus-specific nucleic acids: identity in molecules synthesized in vertebrate and insect cells and characteristic properties of the replicative form RNA.
Virology. 1982 Dec;123(2):273-83. No abstract available.
PMID: 7179740

Wengler G, Boege U, Wengler G, Bischoff H, Wahn K.
The core protein of the alphavirus Sindbis virus assembles into core-like nucleoproteins with the viral genome RNA and with other single-stranded nucleic acids in vitro.
Virology. 1982 Apr 30;118(2):401-10. No abstract available.
PMID: 7090184

Wengler G, Wengler G.
Terminal sequences of the genome and replicative-from RNA of the flavivirus West Nile virus: absence of poly(A) and possible role in RNA replication.
Virology. 1981 Sep;113(2):544-55. No abstract available.
PMID: 7269253

Boege U, Wengler G, Wengler G, Wittmann-Liebold B.
Primary structures of the core proteins of the alphaviruses Semliki Forest virus and Sindbis virus.
Virology. 1981 Aug;113(1):293-303. No abstract available.
PMID: 7269244

Boege U, Wengler G, Wengler G, Wittmann-Liebold B.
Partial amino acid sequences of Sindbis and Semliki Forest virus-specific core proteins.
Virology. 1980 May;103(1):178-90. No abstract available.
PMID: 7368574

Wengler G, Wengler G, Gross HS.
Replicative form of Semliki Forest virus RNA contains an unpaired guanosine.
Nature. 1979 Dec 13;282(5740):754-6. No abstract available.
PMID: 514358

Wengler G, Beato M, Wengler G.
In vitro translation of 42 S virus-specific RNA from cells infected with the flavivirus West Nile virus.
Virology. 1979 Jul 30;96(2):516-29. No abstract available.
PMID: 462816

Wengler G, Wengler G, Gross HJ.
Studies on virus-specific nucleic acids synthesized in vertebrate and mosquito cells infected with flaviviruses.
Virology. 1978 Sep;89(2):423-37. No abstract available.
PMID: 568848

Wengler G, Wengler G, Filipe AR.
A study of neucleotide sequence homology between the nucleic acids of different alphaviruses.
Virology. 1977 May 1;78(1):124-34. No abstract available.
PMID: 860395

Wengler G.
Structure and function of the genome of viruses containing single-stranded RNA as genetic material: the concept of transcription and translation helices and the classification of these viruses into six groups.
Curr Top Microbiol Immunol. 1977;78:239-48. Review. No abstract available.
PMID: 340150

Wengler G, Wengler G.
Localization of the 26-S RNA sequence on the viral genome type 42-S RNA isolated from SFV-infected cells.
Virology. 1976 Aug;73(1):190-9. No abstract available.
PMID: 960559

Wengler G, Wengler G, Warn K.
Isolation and characterization of double stranded RNA containing infectious viral genome RNA from cells infected with Semliki Forest virus.
Arch Virol. 1976;50(1-2):45-53.
PMID: 1259593

Wengler G.
Studies on the synthesis of viral RNA-polymerase-template complexes in BHK 21 cells infected with Semliki Forest virus.
Virology. 1975 Jul;66(1):322-6. No abstract available.
PMID: 1169852

Wengler G.
Comparative studies on polyribosomal, nonpolyribosome-associated and viral 42 S RNA from BHK 21 cells infected with Semliki Forest virus.
Virology. 1975 Jun;65(2):601-5. No abstract available.
PMID: 1168972

Wengler G.
Protein synthesis in BHK-21 cells infected with semliki forest virus.
J Virol. 1975 Jan;17(1):10-9.
PMID: 1206797

Wengler G, Beato M.
Proceedings: Characterization of virus-specific mRNA from cells infected with the togavirus Semliki Forest virus by translation in vitro.
Hoppe Seylers Z Physiol Chem. 1974 Oct;355(10):1267. No abstract available.
PMID: 4461618

Wengler G, Beato M, Hackemack BA.
Translation of 26 S virus-specific RNA from Semliki Forest virus-infected cells in vitro.
Virology. 1974 Sep;61(1):120-8. No abstract available.
PMID: 4472414

Wengler G, Wengler G.
Studies on the polyribosome-associated RNA in BHK21 cells infected with Semliki Forest virus.
Virology. 1974 May;59(1):21-35. No abstract available.
PMID: 4826205

Wengler G, Wengler G.
Medium hypertonicity and polyribosome structure in Hela cells. The influence of hypertonicity of the growth medium on polyribosomes in Hela cells.
Eur J Biochem. 1972 May;27(1):162-73. No abstract available.
PMID: 5049052

Wengler G, Scherrer K.
Ribonucleoprotein particles in HeLa cells. The contamination of the postmitochondrial-cytoplasmic fraction from HeLa cells with ribonucleoprotein particles of mitochondrial origin.
Eur J Biochem. 1972 Jan 21;24(3):477-84. No abstract available.
PMID: 5058596

Roussel A, Lescar J, Vaney M-C, Wengler G, Wengler G, Rey F A.
Crystal structure of the Semliki Forest virus envelope protein E1 in its monomeric conformation: identification of determinants for icosahedral particle formation.
Structure, in press.

Koschinski A, Wengler G, Wengler G, Repp H.
Rare earth ions block the ion pores generated by the class II fusion proteins of alphaviruses and allow analysis of the biological functions of these prores:
J Gen Virol. 2005 Dec; 86 (Pt): 3311:3320.

Wengler G, Koschinksi A, Wegnler G, Repp H.
during entry of alphaviruses, the E1 glycoprotein molecules probably form two separate populations that genberate either a fusion pore or ion-permeable pores.
J Gen Virol. 2004 Jun; 85 (Pt 6): 1695-1701.
PMID: 15166454.


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